Ridding Sunnydale of one slimy demon provides little distraction for Buffy, Xander, and Willow, who are still coping with the aftermath of their relationship woes. Cordy is taking it the hardest, ignoring the vast amount of answering machine messages left by Xander while burning all the pictures of her ex-boyfriend. The next morning, Willow tries once again to patch up her relationship with Oz. Unfortunately, he needs some space and time to make any decisions on the matter. Cordelia arrives at school dressed to kill, but she soon learns that all of her old friends still have no respect for her, even after Xander Harris has left the picture. Harmony introduces Cordy to Anya, a new girl in town, before harshly insulting her former best friend. Anya takes an immediate interest in Cordy's personal troubles. Later that night, Cordy and Anya go to the Bronze, where Xander is also in attendance, along with Buffy and Willow. After getting up to fetch a few drinks, Buffy notices Cordy abruptly exiting, so she follows her into the alley. Before Buffy can get Cordelia to open up and vent her problems, a vampire intervenes. The ensuing fight sends Cordy into a nearby pile of trash. With the last straw exposed, Cordelia identifies Buffy as the source of all of her troubles. As she explains to Anya the next day, none of the bad things in Cordy's life would have ever happened if Buffy never came to Sunnydale. Anya removes her necklace and places it around Cordy's neck. Cordy declares her wish that Buffy never made that fateful trip. At this point, Anya reveals herself to be not quite human and says, "Done." A bright light flashes, and suddenly the Sunnydale High campus is much less crowded than it was a moment ago. Cordelia quickly realizes that Anya must have granted her wish. However, this new version of Sunnydale is not as ideal as she imagined it would be. There's a city curfew that coincides with sunset. The Bronze is no longer the place to be at night. And Xander and Willow, as Harmony tells her, are dead. Night falls as Cordelia wanders the deserted streets of Sunnydale. She encounters Xander and tells him that they have to get Buffy. Willow arrives, and Cordy learns that they are now vampires. Before Xander can kill her, a familiar van pulls up to the scene of the inevitable crime. Giles gets out, warding Xander and Willow off with a cross. Behind him, Oz sits in the driver's seat with a crossbow aimed at the vamps. Larry and a girl named Nancy get out of the van and pull Cordy to safety. Giles gets back inside, and the van takes off. Cordelia is brought to the library, which serves as the main base for the resistance against the vampires. Meanwhile, Xander and Willow return to the Bronze, which is now the headquarters for The Master and his minions. The Master orders Xander and Willow to kill Cordelia before she can contact the Slayer and interfere with his latest scheme. Back at the library, Cordy finally comes to and tells Giles about her wish and that they need Buffy. Unfortunately, neither of them realize that Xander and Willow have infiltrated the library. Locked inside the bookcage, Giles can only hopelessly watch as Xander and Willow sink their fangs into Cordelia, draining her of all of her blood. After the vampires leave, Giles uses an axe from his weapons cabinet to bust open the cage. Larry and Oz arrive, informing Giles that Nancy is now dead. As they pick up Cordy's lifeless body to bring to the incinerator, Giles notices her necklace and removes it. The next morning, Willow plays around with Angel, who the Master has locked up in the basement of the Bronze as punishment. At the library, Giles discovers through his books that the necklace represents Anyanka, the "Patron Saint of Scorned Women". He realizes that Anyanka must have granted a wish that Cordy made which resulted in the world they're living in right now. Giles calls Buffy's Watcher in Cleveland and leaves a message. While driving down the streets later that night, Giles sees some vampires packing a group of humans into the back of a truck. He wards them off with the cross, enabling the humans to escape. However, he is knocked down from behind. Before the vampires can finish him, another challenger enters the fray. Giles watches the vampires face defeat at the hands of this newcomer, then realizes that this new girl is the one and only Buffy Summers. After taking her back to his apartment, Giles informs her of what he's learned concerning Anyanka. In order to reverse all of her wishes and render her powerless, Anyanka's powercenter must be destroyed. Buffy is clearly uninterested in this, and is more concerned with taking out the Master. Buffy goes to the Bronze, which is now deserted. In the basement, she finds Angel locked up behind bars. While she doesn't recognize him, Angel knows exactly who she is from all the time he spent secretly observing her in Los Angeles. Angel leads Buffy to a factory where the Master has unveiled a machine that will revolutionize the lifestyle of vampires everywhere. This device can drain a person's body of all of its blood and dispense it into glasses and cups in mere seconds. Buffy and Angel step in to put a stop to the festivities. While Buffy fights the vampires head-on, Angel frees the human prisoners. In the course of the battle, Angel, Xander, and Willow are dusted. While Buffy continues to fight, Giles summons Anyanka and identifies her glowing necklace as her powercenter. As he rips it from her neck and prepares to smash it, the Master overpowers Buffy and snaps her neck, fulfilling the prophecy in the Pergamum Codex in this reality as well. Giles smashes the necklace, and suddenly Cordelia is standing in front of Anya again. Anya realizes that she is no longer able to grant Cordy's wish. As Cordy walks off, she passes by Buffy, Xander, and Willow, who are still alive and well.